ZOMETA^® effectively inhibits the vicious cycle of bone destruction in patients like Carlo when given 4 mg every 3 to 4 weeks⁹

Bone resorption marker decreases rapidly following administration of ZOMETA on day 1¹⁰
The effect of ZOMETA on bone resorption marker lessens after 3 to 4 weeks¹⁰

Change from baseline in bone resorption marker^*
(after single 4-mg dose of ZOMETA; N=12)¹⁰

Change from baseline in bone resorption marker after single 4-mg dose of ZOMETA graph

*Urinary N-telopeptide/creatinine ratio was chosen as the surrogate marker.

Only dosing every 3 to 4 weeks has been proven effective in reducing
or delaying SREs^2,11-13

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ZOMETA® effectively inhibits the vicious cycle of bone destruction in patients like Carlo when given 4 mg every 3 to 4 weeks9

Only dosing every 3 to 4 weeks has been proven effective in reducingor delaying SREs2,11-13

ZOMETA^® effectively inhibits the vicious cycle of bone destruction in patients like Carlo when given 4 mg every 3 to 4 weeks⁹

Only dosing every 3 to 4 weeks has been proven effective in reducing
or delaying SREs^2,11-13