NCCN and ASCO guidelines support the use of ZOMETA®

National Comprehensive Cancer Network (NCCN) guidelines¹⁷

• ZOMETA or pamidronate should be given (with calcium and vitamin D) to patients with bone metastases with expected survival > 3 months and creatinine <3.0 mg/dL

American Society of Clinical Oncology (ASCO) guidelines¹⁸

• Initiation of therapy

  • — In patients with evidence of bone destruction, IV ZOMETA 4 mg or
    pamidronate 90 mg is recommended
  • — Starting bisphosphonates in women without evidence of bone destruction is
    not recommended
  • — Bone pain should not be a factor



• Duration of therapy

  • — The optimal duration of treatment is not known
  • — "...once initiated, intravenous bisphosphonates [should] be continued until evidence of substantial decline in a patient's general performance status"

ZOMETA is proven in clinical trials to delay and reduce SREs in breast cancer through 25 months⁷

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Achieve maximum efficacy—dose with ZOMETA 4 mg every 3 to 4 weeks

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