About ZOMETA® (zoledronic acid) – Treatment For Skeletal Related Events In Cancer Patients
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metastases and the ZOMETA
mechanism of action

Learn more about the ZOMETA(zoledronic acid) mechanism of action

 
European Summary of Product Characteristics
For non-U.S. Healthcare Professionals: Get information about ZOMETA and its product characteristics

Learn more about ZOMETA product characteristics
 
About ZOMETA® About ZOMETA: defend against SREs across a broad range of tumor types

  Learn more about how ZOMETA® can help your patients with

 

ZOMETA helps stop the debilitating effects of bone metastases

  • The vicious cycle of bone destruction is ongoing and can have serious consequences
    for patients5,6
  • ZOMETA is proven to reduce and delay skeletal-related events (SREs) in multiple
    tumor types2,3,7
    • — 40% reduction in relative risk of SREs in breast cancer
    • — 31% reduction in relative risk of SREs in lung cancer and other solid tumors
    • — 36% reduction in relative risk of SREs in prostate cancer
  • Only dosing every 3 to 4 weeks is proven to protect patients from the devastating effects
    of bone metastases2-4,7
  • Dosing ZOMETA less frequently than at the approved schedule results in a significant loss
    of efficacy8
  • ZOMETA has a well-established safety profile9


References: 1. Harvey HA, Cream LR. Biology of bone metastases: causes and consequences. Clin Breast Cancer. 2007;7(suppl 1):S7-S13. 2. Rosen LS, Gordon D, Tchekmedyian NS, et al. Long-term efficacy and safety of zoledronic acid in the treatment of skeletal metastases in patients with nonsmall cell lung carcinoma and other solid tumors: a randomized, phase III, double-blind, placebo-controlled trial. Cancer. 2004;100:2613-2621. 3. Saad F, Gleason DM, Murray R, et al. Long-term efficacy of zoledronic acid for the prevention of skeletal complications in patients with metastatic hormone-refractory prostate cancer. J Natl Cancer Inst. 2004;96:879-882. 4. Lipton A, Zheng M, Seaman J. Zoledronic acid delays the onset of skeletal-related events and progression of skeletal disease in patients with advanced renal cell carcinoma. Cancer. 2003;98:962-969. 5. Roodman GD. Mechanisms of bone metastasis. N Engl J Med. 2004;350:1655-1664. 6. Lipton A. Future treatment of bone metastases. Clin Cancer Res. 2006;12(suppl 20):6305s-6308s. 7. Kohno N, Aogi K, Minami H, et al. Zoledronic acid significantly reduces skeletal complications compared with placebo in Japanese women with bone metastases from breast cancer: a randomized, placebo-controlled trial. J Clin Oncol. 2005;23:3314-3321. 8. Hatoum HT, Lin SJ, Smith MR, et al. Zoledronic acid and skeletal complications in patients with solid tumors and bone metastases: analysis of a National Medical claims database. Cancer. 2008;113:1438-1445. 9. ZOMETA Summary of Product Characteristics. Novartis Pharma AG.