ZOMETA - Zoledronic AcidZOMETA - Zoledronic Acid Novartis Oncology
HomeZOMETA - International SiteZOMETA - US ResidentsZOMETA - Country Sites
ZOMETA - English ZOMETA - Deutsch ZOMETA - Espanol ZOMETA - Francais ZOMETA - Italiano
ZOMETA-Videos
Blue Arrow View videos on bone
metastases and the ZOMETA
mechanism of action

Learn more about the ZOMETA(zoledronic acid) mechanism of action

 
ZOMETA European Summary of Product Characteristics
Blue Arrow For non-U.S. Healthcare Professionals: Get information about ZOMETA and its product characteristics

Learn more about ZOMETA product characteristics
 
About ZOMETA® About ZOMETA: defend against SREs across a broad range of tumour types

  Learn more about how ZOMETA® can help your patients with

 

ZOMETA helps stop the debilitating effects of bone metastases

  • The vicious cycle of bone destruction is ongoing and can have serious consequences
    for patients5,6
  • ZOMETA is proven to reduce and delay skeletal-related events (SREs) in multiple
    tumour types2,3,7
    • — 40% reduction in relative risk of SREs in breast cancer
    • — 31% reduction in relative risk of SREs in lung cancer and other solid tumours
    • — 36% reduction in relative risk of SREs in prostate cancer
  • Only dosing every 3 to 4 weeks is proven to protect patients from the devastating effects
    of bone metastases2-4,7
  • Dosing ZOMETA less frequently than at the approved schedule results in a significant loss
    of efficacy8
  • ZOMETA has a well-established safety profile9


References: 1. Harvey HA, Cream LR. Biology of bone metastases: causes and consequences. Clin Breast Cancer. 2007;7(suppl 1):S7-S13. 2. Rosen LS, Gordon D, Tchekmedyian NS, et al. Long-term efficacy and safety of zoledronic acid in the treatment of skeletal metastases in patients with nonsmall cell lung carcinoma and other solid tumours: a randomized, phase III, double-blind, placebo-controlled trial. Cancer. 2004;100:2613-2621. 3. Saad F, Gleason DM, Murray R, et al. Long-term efficacy of zoledronic acid for the prevention of skeletal complications in patients with metastatic hormone-refractory prostate cancer. J Natl Cancer Inst. 2004;96:879-882. 4. Lipton A, Zheng M, Seaman J. Zoledronic acid delays the onset of skeletal-related events and progression of skeletal disease in patients with advanced renal cell carcinoma. Cancer. 2003;98:962-969. 5. Roodman GD. Mechanisms of bone metastasis. N Engl J Med. 2004;350:1655-1664. 6. Lipton A. Future treatment of bone metastases. Clin Cancer Res. 2006;12(suppl 20):6305s-6308s. 7. Kohno N, Aogi K, Minami H, et al. Zoledronic acid significantly reduces skeletal complications compared with placebo in Japanese women with bone metastases from breast cancer: a randomized, placebo-controlled trial. J Clin Oncol. 2005;23:3314-3321. 8. Hatoum HT, Lin SJ, Smith MR, et al. Zoledronic acid and skeletal complications in patients with solid tumours and bone metastases: analysis of a National Medical claims database. Cancer. 2008;113:1438-1445. 9. ZOMETA Summary of Product Characteristics. Novartis Pharma AG.